GLP-1s and Hormones: Can You Do Both?
As a provider, one of the most common questions I get from patients is, “Can I take GLP-1s if I’m already on hormone therapy?” And the short answer is: yes, you absolutely can. In fact, for many of my patients, combining the two has been a game-changer.
Let’s break it down.
First, What Are GLP-1s?
GLP-1 receptor agonists—like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)—were originally developed to treat type 2 diabetes. But they’ve quickly become popular for weight loss because they help regulate appetite, slow digestion, and improve insulin sensitivity. In simple terms, they help you feel full faster and stay full longer, while also supporting better blood sugar control.
If you’ve been struggling with weight that won’t budge—especially around the midsection—GLP-1s can be a powerful tool. But what if you’re also on hormone therapy?
Hormone Therapy: Why It Matters
Hormone therapy isn’t just about easing hot flashes or improving sleep. It plays a major role in metabolism, fat distribution, muscle mass, and overall energy. Whether you’re on estrogen, progesterone, testosterone, or a combination, these hormones help your body function more efficiently—and they can absolutely support your weight loss goals.
But here’s the catch: hormone therapy alone doesn’t always move the needle when it comes to stubborn weight. That’s where GLP-1s come in.
The Power of Combining Both
When used together, GLP-1s and hormone therapy can complement each other beautifully. Hormones help regulate how your body stores and burns fat. GLP-1s help control appetite and improve insulin response. Together, they address multiple layers of the weight loss puzzle.
Some studies even suggest that patients on both therapies may experience greater fat loss and better metabolic outcomes than those on GLP-1s alone. Anecdotally, I’ve seen patients feel more energized, less bloated, and more in control of their cravings when we layer these treatments.
What You Can Expect
Here’s what I tell my patients:
Side effects are manageable. GLP-1s can cause nausea, constipation, or fatigue, especially in the beginning. Hormone therapy has its own considerations. But when monitored properly, most patients tolerate the combination well.
We’ll personalize your plan. This isn’t a one-size-fits-all approach. I look at your labs, symptoms, and goals to determine the right dosing and timing for both therapies.
Results take time. You won’t drop ten pounds overnight, but you will start to notice shifts in appetite, energy, and body composition within a few weeks.
Final Thoughts
If you’re already on hormone therapy and considering GLP-1s—or vice versa—know that you don’t have to choose one over the other. In many cases, doing both is the most effective way to support your metabolism, balance your hormones, and finally feel like your body is working with you, not against you.
As always, we’ll walk through the options together and make sure your treatment plan is safe, sustainable, and tailored to your unique needs.
